Publications

2nd december 2025

Synthesis and QSAR Studies of Claramine Derivatives, a New Class of Broad-Spectrum Antimicrobial Agents

Blanchet, M.; Di Giorgio, C. and Brunel, J.M.

10th october 2025

Permeabilize, but ChooseWisely: Selective Antibiotic PotentiationThrough Outer Membrane Disruption in Pseudomonas aeruginosa

Novelli, M.; Brunel, J. M.

1st october 2025

Adaptation to cinnamaldehyde shapes Pseudomonas aeruginosa resistance to major antibiotics.

Dubois E, Gaillot S, Valot B, Bour M, Brunel J. M., Schmidlin L, Plésiat P, Llanes C. 0.

1st september 2025

Accurate antibiotic accumulation in Enterobacteriaceae isolates expressing efflux pumps

Tabcheh, J.; Vergalli, J.; Pages, J. M.; Brunel, J. M.

28 august 2025

Synthesis of New 1,3-bis[(4-(Substituted-Aminomethyl)Phenyl)methyl]benzene and 1,3-bis[(4-(Substituted-Aminomethyl)Phenoxy)methyl]benzene Derivatives, Designed as Novel Potential G-Quadruplex Antimalarial Ligands

Albenque-Rubio, S.; Guillon, J.; Agnamey, P.; Damiani, C.; Savrimoutou, S.; Ronga, L.; Hanot, M.; Zangmo, T.; Pinaud, N.; Moreau, S.; Mergny, J. L.; Marchivie, M.; Moukha, S.; Estela, F.; Dozolme, P.; Cohen, A.; Sonnet, P.

01 august 2025

Efflux-Mediated Resistance in Enterobacteriaceae: Recent Advances and Ongoing challenges to Inhibit Bacterial Efflux Pumps

Rouvier, F.; Brunel, J. M.; Pagès, J. M. and Vergalli, J.

22 july 2025

Bioinspired Syntheses of the Marine Pyridoacridine Alkaloids 2‑Bromo and Bromodeoxyamphimedine and Structure Correction of 2‑Bromoamphimedine

Blyth, N.; Chen, Y.; Rouvier, F.; Brunel, J. M.; Cadelis, M. M. and Copp, B. R.

30 june 2025

Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative.

Andretto de Mattos, B.; Tomas-Grau, R.H.; Alves Fernandes, T.A.; González-Lizárraga, F.; Tourville, A.; Ciss, I.; Brunel, J.-M.; Chehin, R.; Lannuzel, A.; Ferrié, L.; Vozari, R. R.; Figadere, B.; Del Bel, E.; Michel, P. P.

24 june 2025

The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae

Forrest, E.; Lehoux, J.; Guy, A.; Durand, T.; Audebert, S.; Camoin, L.; Spilling, C. D.; Crauste, C.; Canaan, S.; Brunel, J. M.; Bolla, J. M.; Cavalier, J. F.

10 june 2025

Synthetic RNA ligands as activators of type I toxin–antitoxin systems: a novel antimicrobial strategy targeting Helicobacter pylori

C. Martin, M. Panosetti, E.Tesini, S. Azoulay, A. Bugaut, V. Sinou, N. Patino, A. Di Giorgio, F. Darfeuille and M. Duca

10 june 2025

Challenges of Carbapenem-Resistant Enterobacteriaceae in the Development of New β-Lactamase Inhibitors and Antibiotics

Leroux, P.; Bornet, C.; Bolla, J.-M.; Cohen, A.

05 june 2025

Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm

Tareau, A. S. ; Tahrioui, A. ; Gonzalez, M. ; Croize, E. ; Varin Simon, J. ; Barreau, M. ; David, A. ; Reffuveille, F. ; Brunel, J. M. ;Lesouhaitier, O. ; Chevalier, S.

05 june 2025

Assessment of spatial distribution of organic contaminants and metallic compounds on a tropical island' coral reef fish communities

Wejieme, N., Vigliola, L., Parravicini, V., Nicolay, A., Wafo, E., Bustamante, P., Letourneur, Y.

16 April 2025

Anti-Inflammatory and Anticancer Activities of New Monocyclic Indoloβ-Lactam Hybrids

S. Ghaffari, A. Jarrahpour, J. M. Brunel, B. Rastegari, E. Riazimontazer, and E. Turos

02 April 2025

Ohauamines A-D, Structurally Unprecedented Tricyclic Depsi-tripeptides from the New Zealand Ascidian Pycnoclavella kottae.

Chen, D.; Rouvier, F.; Keyzers, R. ; Bourguet-Kondracki, M. L.; Brunel, J. M.; Cadelis, M. M.; Copp, B. R.

27 March 2025

Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage

Alves Fernandes, T. A. ; Tourville, A. ; Ciss, I. ; Ribeiro Silva, R. ; Andretto de Mattos, B. ; Dos Santos Pereira, M. ; Oblaza, M. ; Brunel, J. M. ; Ferrie, L. ; Raisman-Vozari, R. ; Figadere, B. ; Del-Bel, E. ; Michel, P. P.

10 March 2025

Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram-positive Bacteria

Mrunal Patil, Tatiana Munteanu, Gaël Brasseur, Carolina Ferreira, Sofia Santos Costa, Isabel Couto, Mohd Athar, Elisa Asunis, Attilio Vittorio Vargiu, Miguel Viveiros, Carole DiGiorgio, Frédéric Brunel, Jean-Manuel Raimundo, Michel Camplo, Olivier Siri and Jean-Michel Bolla

28 february 2025

Linoleic Fatty Acid from Rwandan Propolis: A Potential Antimicrobial Agent Against Cutibacterium acnes

Rouvier, F.; Abou, L.;Wafo, E. and Brunel, J.M.

31 december 2024

Intracellular Quantification of an Antibiotic Metal Complex in Single Cells of Escherichia coli Using Cryo-X-ray Fluorescence Nanoimaging

Margot Draveny, Hugo Chauvet, Valérie Rouam, Frédéric Jamme, and Muriel Masi

13 december 2024

TWEAK and TNFɑ Pro‑inflammatory Soluble Cytokines and their Specific Autoantibodies Secretion in Multiple Sclerosis Patients

Sylvie Carmona, Jehanne Aghzadi, Thierry Vincent, Pierre Labauge, Clarisse Carra‑Dallière, Sylvain Lehmann, Sophie Desplat‑Jégo and Xavier Ayrignac

13 december 2024

Long-term trends (2002–2016) reveal an increase of mercury levels along
with the decline of several metal elements in striped dolphins (Stenella
coeruleoalba) stranded in the North-West Mediterranean

Julien Dron, Emmanuel Wafo, Florence Chaspoul, Pierre Boissery, Frank Dhermain, Marc Bouchoucha, Philippe Chamaret and Daniel Lafitte

19 november 2024

Antitubercular potential and pH-driven mode of action of salicylic acid derivatives

Laudouze J, Francis T, Forest E, Mies F, Bolla JM, Crauste C, Canaan S, Shlyonsky V, Santucci P, Cavalier JF

13 November 2024

Identification of 2,4-Di-tert-Butylphenol as an Antimicrobial Agent Against Cutibacterium acnes Bacteria from Rwandan Propolis

Florent Rouvier, Lydia Abou, Emmanuel Wafo, Perrine Andre, Julien Cheyrol, Mohamed-Mohsen Khacef, Claude Nappez, Hubert Lepidi and Jean Michel Brunel

19 october 2024

Advances in methods and concepts provide new insight into antibiotic fluxes across the bacterial membrane

Julia Vergalli, Matthieu Réfrégiers, Paolo Ruggerone, Mathias Winterhalter and Jean-Marie Pagès

29 August 2024

The contribution of porins to enterobacterial drug resistance

Anne Davin-Regli, Jean-Marie Pagès, Julia Vergalli

15 July 2024

Optimization of Solid Lipid Nanoparticle Formulation for Cosmetic Application Using Design of Experiments, PART II: Physical Characterization and In Vitro Skin Permeation for Sesamol Skin Delivery

Margot Cassayre, Auriane Oline ,Caroline Orneto, Emmanuel Wafo, Lydia Abou, Alexandre Altié, Magalie Claeys-Bruno, Christophe Sauzet, Philippe Piccerelle

17 Jun 2024

C9-Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α-Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration. ChemMedChem.

Rose C, Tomas-Grau RH, Zabala B, Michel PP, Brunel JM, Chehín R, Raisman-Vozari R, Ferrié L, Figadère B.

28 May 2024

RND Efflux Pump Induction: A Crucial Network Unveiling Adaptive Antibiotic Resistance Mechanisms of Gram-Negative Bacteria.

Novelli M, Bolla JM

26 March 2024

Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities

Di Maio A, Olleik H, Courvoisier-Dezord E, Guillier S, Neulat-Ripoll F, Haudecoeur R, Bolla JM, Casanova M, Cavalier JF, Canaan S, Pique V, Charmasson Y, Baydoun E, Hijazi A, Perrier J, Maresca M, Robin M

24 March 2024

Computational Methods Reveal a Series of Cyclic and Linear Lichenysins and Surfactins from the Vietnamese Marine Sediment-Derived Streptomyces Strain G222

Andrea Castaldi, Bich Ngan Truong, Quyen Thi Vu, Thi Hong Minh Le, Arul Marie, Gaël Le Pennec, Florent Rouvier, Jean-Michel Brunel, Arlette Longeon, Van Cuong Pham, Thi Mai Huong Doan, Marie-Lise Bourguet-Kondracki

13 March 2024

Design, Synthesis, and In Vitro Antimalarial Evaluation of New 1,3,5-Tris[(4-(Substituted-Aminomethyl)Phenoxy)Methyl]Benzenes

Albenque-Rubio S., Guillon J., Agnamey P., Damiani C., Savrimoutou S., Moreau S., Mustière R., Pinaud N., Moreau S., Mergny J.-L., Ronga L., Kanavos I., Marchivie M., Moukha S., Dozolme P., Sonnet P., Cohen A.

22 Feb 2024

Antimicrobial Indole-3-Carboxamido-Polyamine Conjugates Target Bacterial Membranes and Are Antibiotic Potentiators. Biomolecules

Sue K, Cadelis MM, Rouvier F, Bourguet-Kondracki ML, Brunel JM, Copp BR

20 December 2023

Antibiofilm and Antivirulence Properties of 6-Polyaminosteroid Derivatives against Antibiotic-Resistant Bacteria

Delphine Vergoz, Hung Le, Benoit Bernay, Annick Schaumann, Magalie Barreau, Flore Nilly, Florie Desriac, Ali Tahrioui, Jean-Christophe Giard, Olivier Lesouhaitier, Sylvie Chevalier, Jean Michel Brunel, Cécile Muller, Emmanuelle Dé

17 November 2023

Preliminary SAR of Novel Pleuromutilin–Polyamine Conjugates

Sue K, Cadelis MM, Hainsworth K, Rouvier F, Bourguet-Kondracki ML, Brunel JM, Copp BR

7 August 2023

Indole-3-Acetamido-Polyamines as Antimicrobial Agents and Antibiotic Adjuvants

Sue K, Cadelis MM, Gill ES, Rouvier F, Bourguet-Kondracki ML, Brunel JM, Copp BR

7 July 2023

Exploration of Bis-Cinnamido-Polyamines as Intrinsic Antimicrobial Agents and Antibiotic Enhancers

Cadelis MM, Kim J, Rouvier F, Gill ES, Fraser K, Bourguet-Kondracki ML, Brunel JM, Copp BR

7 July 2023

Synthesis and antimicrobial testing of 5-fluorouracil derivatives

Patil M, Serhii K, Garzino F, Gobert Q, Giorgio S, Raimundo JM, Bolla JM, Camplo M.

5 June 2023

Investigation of Naphthyl–Polyamine Conjugates as Antimicrobials and Antibiotic Enhancers

El-Kirat-Chatel S, Varbanov M, Retourney C, Salles E, Risler A, Brunel JM, Beaussart A

June 2023

AFM reveals the interaction and nanoscale effects imposed by squalamine on Staphylococcus epidermidis

El-Kirat-Chatel S, Varbanov M, Retourney C, Salles E, Risler A, Brunel JM, Beaussart A

31 May 2023

Structure–Activity Relationship Studies of Indolglyoxyl-Polyamine Conjugates as Antimicrobials and Antibiotic Potentiators

Cadelis MM, Liu T, Sue K, Rouvier F, Bourguet-Kondracki ML, Brunel JM, Copp BR

23 May 2023

Scope and Limitations of Exploiting the Ability of the Chemosensitizer NV716 to Enhance the Activity of Tetracycline Derivatives against Pseudomonas aeruginosa

Draveny M, Rose C, Pinet A, Ferrié L, Figadère B, Brunel JM, Masi M

15 May 2023

Acacia senegal Budmunchiamines as a Potential Adjuvant for Rejuvenating Phenicol Activities towards Escherichia coli-Resistant Strains

Dofini Magnini R, Pedinielli F, Vergalli J, Ouedraogo N, Remy S, Hilou A, Brunel JM, Pagès JM, Davin-Regli A

10 May 2023

6-Polyaminosteroid Squalamine Analogues Display Antibacterial Activity against Resistant Pathogens

Vergoz D, Nilly F, Desriac F, Barreau M, Géry A, Lepetit C, Sichel F, Jeannot K, Giard JC, Garon D, Chevalier S, Muller C, Dé E, Brunel JM

27 April 2023

Contribution of efflux and mutations in fluoroquinolone susceptibility in MDR enterobacterial isolates: a quantitative and molecular study

Aurélie Ferrand, Julia Vergalli, Claude Bosi, Alix Pantel, Jean-Marie Pagès, Anne Davin-Regli

20 March 2023

α,ω-Diacyl-Substituted Analogues of Natural and Unnatural Polyamines: Identification of Potent Bactericides That Selectively Target Bacterial Membranes

Chen D, Cadelis MM, Rouvier F, Troia T, Edmeades LR, Fraser K, Gill ES, Bourguet-Kondracki ML, Brunel JM, Copp BR

24 February 2023

Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives

Tourville A, Viguier S, González-Lizárraga F, Tomas-Grau RH, Ramirez P, Brunel JM,
Dos Santos Pereira M, Del-Bel E, Chehin R, Ferrié L, Raisman-Vozari R, Figadère B, Michel PP

17 February 2023

Investigation of α,ω-Disubstituted Polyamine-Cholic Acid Conjugates Identifies Hyodeoxycholic and Chenodeoxycholic Scaffolds as Non-Toxic, Potent Antimicrobials

Sue K, Cadelis MM, Troia T, Rouvier F, Bourguet-Kondracki ML, Brunel JM, Copp BR

12 February 2023

Synthesis and antimalarial evaluation of new 1,3,5-tris[(4-(substituted-aminomethyl)phenyl)methyl]benzene derivatives, a novel alternative antiparasitic scaffold

Albenque-Rubio S., Guillon J., Cohen A., Agnamey P., Savrimoutou S., Moreau S., Mergny J.-L., Ronga L., Kanavos I., Moukha S., Dozolme P., Sonnet P.

12 January 2023

Rejuvenating the Activity of Usual Antibiotics on Resistant Gram-Negative Bacteria: Recent Issues and Perspectives

Jinane Tabcheh, Julia Vergalli, Anne Davin-Régli, Noha Ghanem, Jean-Marie Pages, Charbel Al-Bayssari, Jean Michel Brunel

05 October 2022

Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane

Muriel Masi, Julia Vergalli, Ishan Ghai, Andrea Barba-Bon, Thérèse Schembri, Werner M. Nau, Daniel Lafitte, Mathias Winterhalter & Jean-Marie Pagès

6 October 2022

A Framework for Dissecting Affinities of Multidrug Efflux Transporter AcrB to Fluoroquinolones

Julia Vergalli, Hugo Chauvet, Francesco Oliva, Jelena Pajović, Giuliano Malloci, Attilio Vittorio Vargiu, Matthieu Réfrégiers, Paolo Ruggerone & Jean-Marie Pagès